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2 A common milieu of metabolic disorders in heart failure and cognitive impairment 2.1 Heart failure According to epidemiologic analyses, HF is highly prevalent in patients with type 2 diabetes, who are at a higher risk (up to 2-fold in men and 4-fold in women) of developing HF than patients without diabetes (Samson et al., 2016)

Discontinuing an evidence-based IBD therapy like a biologic in favor of an unregulated peptide carries an exceptionally high risk of inducing a severe, uncontrolled disease flare that could lead to hospitalization or surgery